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neuroendocrine dysregulation
Meaning
Disruption of the intricate communication between the brain and the hormone producing glands leads to a persistent state of biological instability. This neuroendocrine dysregulation often presents as a flattened or inverted cortisol curve. Instead of a natural peak in the morning and a decline at night, the body produces stress hormones at the wrong times.
This makes it difficult to stay awake during the day and difficult to sleep at night.
Hormonal Imbalance
The hypothalamic-pituitary-adrenal axis becomes desensitized to feedback and can no longer regulate the stress response effectively. This imbalance means the body no longer knows when to stop producing chemicals like adrenaline. The result is a constant flood of hormones that should only be used in short bursts.
This state costs the individual a substantial amount of energy as the body is constantly fighting against itself to find a baseline.
Systemic Fatigue
Prolonged over-activation of the endocrine system results in a deep physical exhaustion. The person feels a level of tiredness that is not resolved by sleeping or taking breaks. This is because the chemical messengers that usually signal the body to generate energy are no longer working correctly.
Regulatory Failure
The point is eventually reached where the body can no longer maintain internal homeostasis. The person may experience sudden drops in blood sugar and memory loss. These symptoms indicate that the control systems of the body are no longer functioning as a unified whole.
Recovery requires medical intervention to reset the hormonal cycles and a long period of low-stimulus environment.